In Focus: Stem cell therapy

While stem cell therapy has become one of the most promising pillars of regenerative medicine, the journey from research to clinical application is complex, with success depending not only on the biological potential of stem cells, but also on the robustness, standardization and reproducibility of workflows.   

In this In Focus feature, we’ll investigate how to build reliable and robust stem cell workflows by examining key factors that influence their success. These include the importance of consistent reagent performance, the role of controlled culture conditions, and the benefits of adopting serum-free or animal component-free systems early in the process.  

Additionally, we’ll explore how aligning workflows with GMP requirements from the outset can not only streamline the transition to clinical-grade production but also minimize the need for costly revalidation down the line.  

Infographic
Stem cell therapy: Building reproducible and scalable workflows 

Explore the key stages of stem cell therapy development and the critical steps needed to ensure consistency, scalability, and functionality throughout the workflow. As stem cell therapy continues to evolve, the need for robust, reproducible and scalable workflows has become paramount. This infographic delves into the end-to-end development process, highlighting the steps needed to ensure consistency and functionality.   

Interview

Laying the foundations for a robust stem cell workflow

In this interview, Hagen Wieland shares his expertise on navigating the journey from research-stage workflows to translation-ready processes. From addressing variability in stem cell culture systems to ensuring smooth GMP transitions, Hagen provides invaluable insights into the critical decisions researchers must make early in development. He also highlights the importance of adopting defined systems, mitigating comparability risks during scale-up, and leveraging cryopreservation to maintain stem cell functionality.  

Resources

Characterization of mesenchymal stem cells

Cell cryopreservation in Cryo-SFM Plus

In association with PromoCell.