Regenerative immune cells enhanced for antitumor therapy

Written by Harriet Wall

Researchers at the Georgetown University Medical Center (DC, USA) have developed ‘super immune cells’ – T cells that have been reprogrammed into highly active regenerative stem cell-like memory (TSCM) cells, which display strong antitumor activity. Their research, which was recently published in Nature Immunology, focused on the inhibition of a protein known as MEK1/2. Many MEK inhibitors have been developed to treat melanoma and this study has now provided insight into their mechanism of action. “Although immunotherapies have improved survival for cancer patients over recent years, survival rates remain suboptimal. Therefore, there is an urgent need to develop novel, more...

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