Urothelial cancer organoids show promise as a tool for bladder cancer research

Researchers from the University Medical Center Utrecht (Netherlands) have provided proof of concept of tissue-based bladder tumoroids mimicking parental tumors. As preclinical model systems for bladder cancer are crucial for developing therapeutic strategies tailored to individual tumor characteristics, these findings provide a promising new avenue for bladder cancer pathogenesis research.   Their research was published in the journal National Library of Medicine.   Bladder cancer ranks among the top ten most common tumor types worldwide and continues to represent a growing healthcare problem.   Bladder tumors are genetically and molecularly very heterogenous, causing precision medicine to fail in the area of bladder cancer. Currently, therapeutic decision-making involves assessing a single fragment of tumor tissue.  ...