Research Article: Fibrin-based microsphere reservoirs for delivery of neurotrophic factors to the brain

The Nanomedicine Special Focus Issue on ‘Engineering the nanoenvironment for regenerative medicine’ also highlights that nanobiomaterials are also increasingly being recognized for their significant potential in targeted delivery of drug payloads, and particularly for drug delivery to inaccessible anatomical or intracellular compartments. This is indicated in an original article by Juhi Samal et al. who present research on hollow fibrin microspheres and how they may be employed to protects neural growth factor activity and promote a controlled release in vivo. The authors demonstrate how these microspheres offer tuneable loading efficiency and maintaining their bioactive form after release in vivo. Aim:...