The importance of detailed epigenomic profiling of different cell types within organs

Open Access Epigenomics Review by Theresa Stueve et al. (University of Southern California, Los Angeles, CA, USA) illustrating the importance of investigating cell epigenomes for regenerative medicine and other applications.

Comprehensively profiling the body’s distinct epigenetic landscapes may allow researchers to verify cell types used in regenerative medicine and to determine the epigenetic effects of disease, environmental exposures and genetic variation. In this Review by Theresa Stueve et al. from the University of Southern California (Los Angeles, CA, USA), the lung is utilized as an example to highlight the importance of understanding the epigenetic basis for cell phenotype specification and describes specific instances in which cell type-specific epigenomic information might be leveraged.

Stueve TR, Marconett CN, Zhou B, Borok Z, Laird-Offringa IA. The importance of detailed epigenomic profiling of different cell types within organs. Epigenomics 8(6), 817—829 (2016).

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