In Focus: Growing organoids
Organoids are three-dimensional, miniaturized tissue constructs that can be generated from pluripotent stem cells, adult stem cells, or primary tissues and closely mimic the characteristics of their equivalent in vivo organ. In recent years, organoid technology has become increasingly popular for regenerative medicine applications, such as the development of cell and gene therapies, the generation of biobanks and even tissue transplantation.
In this In Focus feature, in association with PromoCell, we will review methods for generating robust organoid models and evaluate the benefits and limitations of different 3D culture systems for various regenerative medicine applications.
Infographic
This infographic investigates the similarities and differences between cancer organoids and tumorspheres to help you determine which model will work best for your application. It also lays out a simple five-step workflow for setting up a robust and high-throughput cancer organoid assay.
Interview
Top tips for incorporating organoids into your research: an interview with Elfie Rödel
Here, Elfie Rödel, Project Manager in the Development Department of PromoCell (Heidelberg, Germany), discusses selecting appropriate 3D cultures for different applications, the challenges of establishing and using these models and shares her best practice tips for working with these exciting new cultures.
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