In Focus: Human leukocyte antigens
The human leukocyte antigen (HLA) complex plays a crucial role in cell and gene therapies, as well as regenerative medicine, due to its involvement in the immune response. It consists of cell-surface proteins that help to regulate immune responses in humans by enabling the immune system to recognize and respond to foreign molecules.
To obtain research data that can be effectively translated into cell therapies and personalized medicines, it is essential to use relevant HLA-typed cells for in vitro experiments. In this In Focus feature, we’ll explore the role of HLA-typed cells in research, focusing on how they contribute to personalized medicine and the development of tailored treatments.
Infographic
This infographic highlights the key advantages of using HLA-typed cells, including greater control, faster testing and development, human-specific modeling and precise testing with reduced off-target interactions.
Interview
HLA typing in adoptive immunotherapy and disease research
Courtney Stewart explains why HLA type is crucial in both basic and clinical regenerative medicine research. She then dives into how HLA compatibility can influence the outcome of immunotherapy among patients and gives us her insight into the current challenges of integrating HLA typing into clinical practice.
Resources
The human leukocyte antigen complex
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