Novel cell culture protocol developed to induce mouse embryonic stem cell differentiation

Researchers have developed a new, more accurate, method to stimulate mouse embryonic stem (ES) cell differentiation with increased expression of LIM homeobox 1 (Lhx1) – a key biomarker. Researchers from ETH Zürich (Switzerland) have developed a novel cell culture protocol that can stimulate the differentiation of mouse embryonic stem (ES) cells – providing a new avenue for stem cell research and development. A pre-print of their research was recently published on bioRxiv. Previously, researchers have induced the differentiation of mouse ES cells into spermatogonial stem cells (SSCs) through chemical intervention. However, these cells lacked an enhanced expression of SSC biomarkers,...