One-step isolation and activation with flexible active release to optimize T-cell phenotype

Research and clinical outcomes have established that delivering a higher-quality pool of early T-cell phenotypes is key to improving the reliability and longevity of therapeutic outcomes. To aid in the production of the desired phenotypes, Gibco™ CTS™ Detachable Dynabeads™ CD3/CD28 (active-release beads) was developed. This builds upon the one-step isolation and activation process using the CTS Dynabeads CD3/CD28 magnetic Dynabeads (passive-release beads) and allows for control of activation through user-defined dissociation of the active-release beads at any time after activation. This feature was designed to help preserve an early T-cell phenotype and shorten the T-cell manufacturing process to a few days.

This content was supplied by Thermo Fisher Scientific.