Endothelial cell tube formation assay

Angiogenesis is a tightly regulated process that is balanced by pro- and anti-angiogenic signals including integrins, chemokines, angiopoietins, oxygen sensing agents, junctional molecules and endogenous inhibitors. It is a hallmark of over 50 different disease states, and its dysfunction is implicated in cancer, psoriasis, various eye diseases, rheumatoid arthritis, asthma and other autoimmune diseases, infectious diseases, coronary arterial diseases, stroke, atherosclerosis and impaired wound healing, among others.

This Application Note introduces tube formation assays for analyzing angiogenesis, detailing a protocol for this method.

This interview is part of the RegMedNet In Focus on angiogenesis. Discover expert opinions on this topic by visiting our feature homepage.

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RMN – 2024 – Q2 – IF – angiogenesis – content – Endothelial_cell_tube_formation_web